Guangzhou Huangzhipai Packaging Machinery Co., Ltd.

Guangzhou Huangzhipai Packaging Machinery Co., Ltd.

What should be done if the powder medicine packaged in a Vial bottle becomes lumpy?

2026 01/22

What should be done if the powder medicine packaged in a West Lin bottle becomes lumpy?
Quality issues:
Powdered medicines packaged in vials have developed clumping after being stored for some time.
Reason analysis:
(1) The drugs have a high moisture content - if the powdered drugs are not adequately dried, and their moisture content is high, they are prone to clumping. This can be verified by testing the moisture content of the drugs.
(2) Poor sealing of the packaging material - if the fit between the vial cap and the vial mouth is poor, such as if the fit is not tight, the cap is loose, or the opening force is low, and the sealing performance is poor, it can easily allow external water vapor to enter the vial, causing the powdered drugs in the packaging to develop clumping problems. This can be verified by checking the opening force, compatibility, and sealing performance (negative pressure method).
(3) Equipment problems during filling and sealing - if the sealing of the vial during sealing is loose due to equipment aging or incompatibility, this can be verified by checking the opening force, compatibility, sealing performance (negative pressure method).
Suggestions:
- Pay attention to moisture testing of the drugs.
- Pay attention to monitoring the main performance indicators such as the opening force of the vial cap, the negative pressure test for sterilization, the compatibility between the vial cap and the vial, and the sealing performance.